Trazodone is an antidepressant, which doesn’t belong to any group of these drugs. It has a broad range of effects, including anxiolytic, thymoleptic, miorelaxing and sedative effect. It has a little effect on the re-uptake of dopamine and noradrenaline, acting mostly on the reuptake of serotonin. In its effectiveness, this drug is comparable to the tricyclic antidepressants, exceeding them greatly in terms of security and slighter pronounce of side effects.
Trazodone fights successfully against such anxiety manifestations as fear, tension, insomnia irritability, and some somatic manifestations, such as: headache, increased heart rate, myalgia, frequent urination and excessive sweating. The drug has a positive influence on sleep, normalizing its physiological structure. It results in the increased duration and profundity of sleep. The drug promotes the return of sexual appetite and potency, blocks the craving for ethanol, and is applied effectively in the treatment of patients with alcohol withdrawal (in case of addiction to benzodiazepine).
At that, the medicine is characterized with the high level of safety, doesn’t inhibits the MAO. It is also not addictive, doesn’t cause anticholinergic effect, and by no means affects the change of body mass. In half of patients, therapeutic effect is observed within 3- 7 days of using Trazodone (this is particularly true for the stabilization of sleep and the removal of anxiety), 25% – in 2-4 weeks.
Trazodone is especially efficient for the treatment of depressions, accompanied by night sleep disorders. About 67 % of patients, who have taken Trazodone, observed the improvement of sleep quality, its profundity, and got rid of night awakenings, in contrast to the 13% of testees, who have taken placebo. Besides, the drug has proved itself in the fight against insomnia, caused by antidepressants.
Indications for use
Depressions of different origins: neurotic, endogenous, somatogenic and psychotic, including those with the accompanied with a heightened anxiety. There are enough reasons to start taking this drug, if your depression has at least 4 of the following signs: psychomotor retardation or agitation, sleep appetite disorders, decreased interest in life, the absence of sexual interest, slow thinking, enhanceable fatigueability, feeling of guilt, suicidal tendency, as
- well as the reduced focus ;
- different phobias;
- drug addiction to benzodiazepines;
- acute alcohol withdrawal;
- impotence /low libido;
- prevention of migraines.
You can’t use Trazodon if you have hypersensitivity to this substance, during pregnancy and breastfeeding, patients with ventricular arithmia, priapism in anamnesis, tachycardia, as well as at an early recovery stage of myocardial infarction.
The most common side effects are enhanceable fatigueability, dizziness, state of agitation, headache, arrhythmia, insomnia, sickness, vomiting, low blood pressure, dry and bitter mouth, diarrhea, nasal congestion, and also allergic reactions.