Amaryl is pharmacological drug that is designed to reduce the blood sugar level of a person during a diabetes of the second type, means, non-insulin dependent diabetes. Active ingredient of Amaryl is glimepiride.


Amaryl assigned to receive during non-insulin diabetes. Its main active substance, glimepiride is a stimulator of insulin production by the pancreas and its subsequent admission into the blood.

Insulin, in turn, is a factor in lowering blood sugar. Glimepiride also improves the exchange of potassium in the body cells and prevents the formation of atherosclerotic plaques on the vascular walls.


Contraindications for use of Amaryl are:

  • diabetes of the first type- insulin-dependent;
  • diabetic ketoacidosis (a disease which is a complication of diabetes in the first type);
  • renal and hepatic disease in severe forms;
  • diabetic coma, precoma (before diabetic coma);
  • lactase deficiency, glucose-galactose malabsorption, individual galactose intolerance;
  • childhood;
  • hypersensitivity to any component of the drug;
  • during pregnancy and lactation.

Dosage and Administration

Amaryl tablets are taken by mouth. They are swallow whole, washed down with plenty of water (at least a cup of water per tablet). Amaryl should be taken before breakfast or during it.

Treatment begins with a minimum dosage of the drug, no more than one milligram per day. Then, gradually, depending on the health of the patient the doctor may increase the dose of Amaryl once every two weeks according to the following scheme: 1-2-3-4-6 mg.

Side effects

One of the most common side effects that gives Amaryl is hypoglycemia, it means a sharp drop of sugar in blood. In addition, this drug is able to cause such negative phenomena as:

cardiovascular system: tachycardia, bradycardia, angina and hypertension;
hemopoietic system: anemia, thrombocytopenia, pancytopenia, leukopenia, granulocytopenia, agranulocytosis;
the central nervous system: insomnia or drowsiness, headache, increased aggressiveness, restlessness, decreased reaction rate, speech impairment, loss of consciousness, tremor of limbs, convulsions;
the digestive system: nausea, vomiting, cholestasis, hepatitis, jaundice, feeling of heaviness in the stomach, diarrhea;
immune system: allergic reactions such as urticaria, vasculitis, skin rash, itchiness;
the visual system: visual disturbances