Pamelor (Nortriptyline) belongs to the group of tricyclic antidepressant and is similar in its chemical structure to Amitriptyline. But compared to the last one, Pamelor has a moderate stimulatory and mood improving action with the most minimal sedative effect. It successfully fights hypochondriac syndrome. The antidepressive effect of the drug comes fast, in the first two weeks of treatment.

Indications for use

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    • The treatment of all forms of endogenous depressions (neurotic and reactive);
    • The treatment of depressive state in manic depression;
    • The treatment of involuntional depression;
    • The treatment of apathetic syndromes, caused by cerebral atherosclerosis;
    • In combination with Amitriptyline, it can be used for the treatment of depressions, caused by the treatment with reserpine;
    • In combination with neuroleptics, it can be used in for the treatment of depressions, resulting from the therapy of schizophrenic psychosis.



The drug intake is strictly forbidden to the patients with myocardial infarction and depressions with suiide attempts. Besides, the drug can be taken together with thymeretics. The interval between the courses of treatment with thymeretics and Nortriptyline should be at least 2 weeks.

Directions for use and dosage

The dose must be prescribed as individually as possible, based on the reaction of the patient’s body to the drug. At that the elderly patients must take the reduced dose of Nortriptyline. Usually, the antidepressant is taken 3-4 times a day, while an average daily dose is 75-100 mg. In case of acute need, the dose can be increased to 150 mg a day. It is unadvisable to exceed this dose. Once the remission starts, it is reasonable to reduce the dose to the minimal supportive one.

Side effects

The most common side effects: constipation, dry mouth, accommodation and urination disorder, agitation, tachycardia and heart rate disorder.