Alli is a lipid-lowering drug, which is indicated for the treatment of obesity.
Pharmacological properties
The active ingredient of the drug has the ability to block enzymes in the stomach and intestine that break down fats (lipase). At the same time disintegration of complex fat to monoglycerides and fatty acids is impossible, they are not absorbed, and output of the intestines unchanged. During receiving Alli components of fat digestion are not absorbed in the blood, creating a calorie deficit in the body, what results to a loss of its own, previously deferred excessive adipose tissue.
The received dose of Alli exhibits its activity, it is completely without affecting the system action to the body. Therapeutic dose blocks the digestion about 30% of fats. Alli, according to studies, hasn’t adverse effect on the properties and composition of bile, on the speed of movement through the digestive tract bolus or gastric acidity.
Indications
Alli drug is used in the presence of obesity and as a consequence, to reduce unnecessary weight. Drug is helpful simultaneously with the low-calorie diet. It is used as prevention and reducing the risk of re-gain weight, which is possible after its initial reduction.
Contraindications
The drug Alli has contraindications:
chronic malabsorption syndrome;
hypersensitivity;
cholestasis.
There are limitations to the use:
nephrolithiasis;
hyperoxaluria in history;
childhood.
You should be careful if you have hyperoxaluria in history, oxalate and calcium stones in the kidneys.
Dosing and Administration
It must be ensured in the absence of organic causes of obesity before prescribing the drug.
During the therapy a balanced low-calorie diet is desirable, in which fat provides no more than 30% of calories.
The drug Alli is taken as while eating, so no later than one hour after a meal, 3 times a day 120 mg. You can miss single dose in the case of ingestion, which is not composed of fat, either in the case of food passes.
Side effects
Admission of Alli medication leads to side effects of:
GI:
flatulence;
oily discharge;
compelling urge to defecate;
fatty / oily stools;
increased frequency of defecation;
nausea;
stomach ache;
discomfort in the rectum;
infectious diarrhea;
fecal incontinence.
The feeling of nausea
CNS and sensory organs:
depression;
fatigue;
anxiety;
sleep disturbances;
dizziness;
headache.
Respiratory system:
otitis;
infections of the lower and upper respiratory tract.
Urogenital System:
urinary tract infection;
vaginitis;
irregular menstrual cycle.
Skin:
dry skin;
rash.
Rash
Musculoskeletal:
tendonitis;
violation of joint function;
pain in the lower extremities;
myalgia;
arthritis.
Allergic reactions:
hives;
anaphylaxis;
angioedema;
rash;
itching.
Other:
feet swelling;
flu
tooth and gum disease.
The most common side effects observed from the gastrointestinal tract.
