According to the instruction, the action of Cymbalta is related to the process of the reuptake of serotonin, as in many other drugs of such direction. The drug can be found under the international name Duloxetine, which is also an active component.

Indications for the use of Cymbalta

This drug is recommended to the patients with depressive states or diabetic neuropathy in its painful form. The active substance of Cymbalta stops the painful syndromes, caused by this disease.


Like every drug, Cymbalta has its contraindications. The treatment with this drug is forbidden in case of the following diseases and states:

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  • Hypersensitivity to the active substance Duloxetine;
  • simultaneous intake of MAO inhibitors;
  • breastfeeding period;
  • diagnosed closed-angle glaucoma;
  • the age under 18.


The drug can be taken with caution and only under the supervision of a doctor in cases of exacerbation of manic and elated state (and not only at the current moment, but also in the anamnesis). The same applies to epilepsy (including anamnesis). The patients with renal and liver failure, risk of developing closed-angle glaucoma must be under medical supervision.

Possible side effects of treatment

In approximately 10% of cases (which is considered a common reaction) the intake of Cymbalta can cause vertigo, sleep disorders (insomnia, and, on the contrary, drowsiness), sickness, dry mouth, constipation and headache.

Less frequent side effects are vomiting, diarrhea, decrease in appetite and body mass, tremor, sweating, decreased libido, blurred vision, hot flush in women, and decreased potency and ejaculation disorders in men.

Against the background of the therapy with Cymbalta, the patients with diabetic neuropathy can have high glucose blood level (if the test is made on an empty stomach).

The side effects may be also observed in case of withdrawal of the drug. The patients reported the headaches, vertigo and sickness.

The overdose can cause vomiting, reduced appetite, ataxia, seizures and tremor. There is no antidote for Cymbalta, that’s why you should strictly observe the dosage, prescribed by the doctor.

How to take the drug

Take Cymbalta irrespectively of the mealtime. Pharmaceutical form: enterosoluble capsules. They must be swallowed as a whole. It is unadvisable to dilute it with water or mix with meal.

The drug is usually taken once a day in dosage of 60 mg. If necessary, it can be increased to 120 mg and taken twice a day. The maximal daily dosage is 120 mg.

In renal failure, the initial dose is reduced to 30 mg a day.

It should be remembered that the intake of Cymbalta can slow down the psychomotor abilities and impair the memory function.