Different forms of depressions (low spirits / endogenous, psychotic, neurotic, somatogenic, etc.), accompanied by anxiety and tension.

Due to the good tolerance and absence of cholinergic effect, Desyrel is widely used in the treatment of older patients with organic diseases of central nervous system, and in the complex treatment of patients with somatic (internal diseases), complicated by mental disorders (anxiety, tension, etc.).

Directions for use

The drug is taken orally, sometimes intramuscularly and intravenously. The initial dose (in oral intake) is 50 mg 3 times a day, and then depending on the type and severity of depression- to 300-500 mg a day. Therapeutic effect is usually observed 3-7 days after the beginning of treatment.
The dose for intramuscular and intravenous introduction is 50 mg, as an anxiolytic (anti-anxiety) drug for premedication (the use of drugs for the preparation to narcosis or local anesthesia) before the surgical intervention.

Side effects

Fatigue, drowsiness, headache, vertigo, insomnia and low blood pressure. They are rare and can be caused by the reduction of dose.


The drug can’t be taken simultaneously with MAO inhibitors.

Desyrel stabilizes the emotional state, improves mood, and decreases the alcohol addiction in patients with chronic alcoholism in withdrawal syndrome and remission. Withdrawal symptoms in patients with benzodiazepine dependence, Desyrel is effective in treatment of mixed anxiety-depressive disorder and trouble sleeping. In remission, benzodiazepines can be completely replaced by Trazodone.