– Essential hypertension;
– Nephropathy with arterial hypertension and type 2 of diabetes (as part of combination anti-hypertensive therapy).


– Pregnancy;
– Lactation;
– Child and adolescence to 18 years (effectiveness and safety haven’t been established);
– Lactose intolerance, lactase deficiency and syndrome of glucose-galactose malabsorption;
– Hypersensitivity to the drug.

You should use it carefully with stenosis of the aortic or mitral valve, hypertrophic obstructive cardiomyopathy, dehydration, hyponatremia, diarrhea, vomiting, a diet with limited consumption of salt, diuretic therapy, bilateral stenosis of renal artery, unilateral stenosis of the one kidneys artery, chronic heart failure.


The drug is taken orally, the tablet is swallowed whole with water. The initial and maintenance dose is 150 mg 1 time / day, regardless of the meal. Use of the drug in this dose provides a more optimal 24-hour blood pressure control than 75 mg / day. However, in some cases, especially in patients on hemodialysis, or patients with the age over 75 years, initial dose should be 75 mg.

During the insufficient therapeutic effect when you use the drug at a dose of 150 mg 1 time / day, the dose can be increased to 300 mg or it is necessary to assign other anti-hypertensive agents. In particular, it has been shown that prescription of a diuretic such as hydrochlorothiazide strengthened Avapro action.
In patients with hypertension and diabetes of type 2, treatment should be started at a dose of 150 mg 1 time / day and gradually increase to 300 mg – dose, which is the preferred maintenance dose for treatment of nephrophathy.

Contraindications and interactions with other drugs

Before taking Avapro, tell your doctor and pharmacist if you are allergic to Avapro, any other medications, or any of the ingredients of Avapro. Ask your pharmacist for a list of ingredients of the drug.

Tell your doctor if you have diabetes and you’re taking aliskiren. Also tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Don’t forget to mention any of the following medicines: benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, trandolapril; Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen; celecoxib; diuretics; potassium supplements. Your doctor may need to change the doses of your medications or monitor closely for side effects.

Tell your doctor if you have or ever have been had heart failure or kidney disease or if you are breastfeeding. Avapro may cause dizziness and fainting. Tell your doctor if you have any of these problems in the course of treatment.